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Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage
Multiply damaged sites (MDSs) consist of two or more damages within 20 base pairs (bps) and are introduced into DNA by ionizing radiation. Using a plasmid assay, we previously demonstrated that repair in E.coli generated a double-strand break (DSB) from two closely opposed uracils when uracil DNA gl...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1704278/ https://ncbi.nlm.nih.gov/pubmed/16337438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2005.10.009 |
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