ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

The phosphatidyl inositol 3-kinase-like kinases (PIKKs), ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) regulate parallel damage response signalling pathways. ATM is reported to be activated by DNA double-strand breaks (DSBs), whereas ATR is recruited to single-stranded regions...

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Detalhes bibliográficos
Main Authors: Stiff, Thomas, Walker, Sarah A, Cerosaletti, Karen, Goodarzi, Aaron A, Petermann, Eva, Concannon, Pat, O'Driscoll, Mark, Jeggo, Penny A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698893/
https://ncbi.nlm.nih.gov/pubmed/17124492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601446
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