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Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1
Ataxia telangiectasia and Rad3-related (ATR) is a phosphoinositol-3-kinase like kinase (PIKK) that initiates a signal transduction response to replication fork stalling. Defects in ATR signalling have been reported in several disorders characterized by microcephaly and growth delay. Here, we gain in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3708519/ https://ncbi.nlm.nih.gov/pubmed/18664457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn220 |
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