Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1

Ataxia telangiectasia and Rad3-related (ATR) is a phosphoinositol-3-kinase like kinase (PIKK) that initiates a signal transduction response to replication fork stalling. Defects in ATR signalling have been reported in several disorders characterized by microcephaly and growth delay. Here, we gain in...

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Bibliografiske detaljer
Main Authors: Stiff, Tom, Cerosaletti, Karen, Concannon, Patrick, O'Driscoll, Mark, Jeggo, Penny A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708519/
https://ncbi.nlm.nih.gov/pubmed/18664457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn220
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