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The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels

TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells. TRPV4 is activated by several stimuli, but it is largely unknown how the activity of this channel is terminated. Here, we show that ubiquitination represents an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wegierski, Tomasz, Hill, Kerstin, Schaefer, Michael, Walz, Gerd
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698878/
https://ncbi.nlm.nih.gov/pubmed/17110928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601429
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