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The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels

TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells. TRPV4 is activated by several stimuli, but it is largely unknown how the activity of this channel is terminated. Here, we show that ubiquitination represents an...

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Detalhes bibliográficos
Main Authors: Wegierski, Tomasz, Hill, Kerstin, Schaefer, Michael, Walz, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698878/
https://ncbi.nlm.nih.gov/pubmed/17110928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601429
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