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Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B)

The Wilson protein (ATP7B) is a copper-translocating P-type ATPase that mediates the excretion of excess copper from hep-atocytes into bile. Excess copper causes the protein to traffic from the TGN (trans-Golgi network) to subapical vesicles. Using site-directed mutagenesis, mutations known or predi...

詳細記述

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書誌詳細
主要な著者: Cater, Michael A., La fontaine, Sharon, Mercer, Julian F. B.
フォーマット: Artigo
言語:Inglês
出版事項: Portland Press Ltd. 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698686/
https://ncbi.nlm.nih.gov/pubmed/16939419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061055
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