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Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.
The Wilson protein (ATP7B) is a copper-transporting CPx-type ATPase defective in the copper toxicity disorder Wilson disease. In hepatocytes, ATP7B delivers copper to apo-ceruloplasmin and mediates the excretion of excess copper into bile. These distinct functions require the protein to localize at...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224206/ https://ncbi.nlm.nih.gov/pubmed/14998371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031804 |
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