SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR

Cholesterol accumulation and removal are regulated by two different transcription factors. SREBP-2 (sterol-regulatory-element-binding protein-2) is best known to up-regulate genes involved in cholesterol biosynthesis and uptake, whereas LXR (liver X receptor) is best known for up-regulating choleste...

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Autores principales: Wong, Jenny, Quinn, Carmel M., Brown, Andrew J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698594/
https://ncbi.nlm.nih.gov/pubmed/16901265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060914
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