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Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

LXRα and -β are nuclear receptors that regulate the metabolism of several important lipids, including cholesterol and bile acids. Previously, we have proposed that LXRs regulate these pathways through their interaction with specific, naturally occurring oxysterols, including 22(R)-hydroxycholesterol...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Janowski, Bethany A., Grogan, Michael J., Jones, Stacey A., Wisely, G. Bruce, Kliewer, Steven A., Corey, Elias J., Mangelsdorf, David J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15128/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9874807/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.1.266
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