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Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

LXRα and -β are nuclear receptors that regulate the metabolism of several important lipids, including cholesterol and bile acids. Previously, we have proposed that LXRs regulate these pathways through their interaction with specific, naturally occurring oxysterols, including 22(R)-hydroxycholesterol...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Janowski, Bethany A., Grogan, Michael J., Jones, Stacey A., Wisely, G. Bruce, Kliewer, Steven A., Corey, Elias J., Mangelsdorf, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15128/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9874807/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.1.266
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