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Nucleotide-Resolution Mapping of Topoisomerase-Mediated and Apoptotic DNA Strand Scissions at or near an MLL Translocation Hotspot

The emergence of therapy-related acute myeloid leukemia (t-AML) has been associated with DNA topoisomerase II (TOP2)–targeted drug treatments and chromosomal translocations frequently involving the MLL, or ALL-1, gene. Two distinct mechanisms have been implicated as potential triggers of t-AML trans...

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Detaylı Bibliyografya
Asıl Yazarlar: Mirault, Marc-Edouard, Boucher, Patrick, Tremblay, Alain
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society of Human Genetics 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698565/
https://ncbi.nlm.nih.gov/pubmed/17033956
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