Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis

The insulin receptor substrate (IRS) proteins are cytoplasmic adaptors that organize signaling complexes downstream of activated cell surface receptors. Here, we show that IRS-1 and IRS-2, despite significant homology, play critical yet distinct functions in breast cancer, and we identify specific s...

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Detalhes bibliográficos
Main Authors: Ma, Zhefu, Gibson, Shannon L., Byrne, Maura A., Zhang, Junran, White, Morris F., Shaw, Leslie M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698550/
https://ncbi.nlm.nih.gov/pubmed/17030605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01032-06
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