Mammary Tumorigenesis and Metastasis Caused by Overexpression of Insulin Receptor Substrate 1 (IRS-1) or IRS-2

Insulin receptor substrates (IRSs) are signaling adaptors that play a major role in the metabolic and mitogenic actions of insulin and insulin-like growth factors. Reports have recently noted increased levels, or activity, of IRSs in many human cancers, and some have linked this to poor patient prog...

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Autori principali: Dearth, Robert K., Cui, Xiaojiang, Kim, Hyun-Jung, Kuiatse, Isere, Lawrence, Nicole A., Zhang, Xiaomei, Divisova, Jana, Britton, Ora L., Mohsin, Syed, Allred, D. Craig, Hadsell, Darryl L., Lee, Adrian V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698542/
https://ncbi.nlm.nih.gov/pubmed/17030631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00260-06
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