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Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the α6β4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion
Expression of the α6β4 integrin increases the invasive potential of carcinoma cells by a mechanism that involves activation of phosphoinositide 3-OH kinase (PI3K). In the present study, we investigated the signaling pathway by which the α6β4 integrin activates PI3K. Neither the α6 nor the β4 cytopla...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2001
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC87234/ https://ncbi.nlm.nih.gov/pubmed/11438664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.15.5082-5093.2001 |
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