Kinase Activity of Overexpressed HipA Is Required for Growth Arrest and Multidrug Tolerance in Escherichia coli

Overexpression of the HipA protein of the HipBA toxin/antitoxin module leads to multidrug tolerance in Escherichia coli. HipA is a “toxin” that causes reversible dormancy, whereas HipB is an antitoxin that binds HipA and acts as a transcriptional repressor of the hipBA operon. Comparative sequence a...

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Bibliographic Details
Main Authors: Correia, Frederick F., D'Onofrio, Anthony, Rejtar, Tomas, Li, Lingyun, Karger, Barry L., Makarova, Kira, Koonin, Eugene V., Lewis, Kim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Microbial Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698217/
https://ncbi.nlm.nih.gov/pubmed/17041039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01237-06
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