Role of unusual P-loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance

HipA is a bacterial serine/threonine protein kinase that phosphorylates targets to effect persistence and multidrug tolerance. HipA is Autophosphorylation of residue Ser150 is a critical regulatory mechanism of HipA function. Intriguingly, Ser150 is not located on the activation loop as in other kin...

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Pubblicato in:Cell Rep
Autori principali: Schumacher, Maria A., Min, JungKi, Link, Todd M., Guan, Ziqiang, Xu, Weijun, Ahn, Young-Ho, Soderblom, Erik J., Kurie, Jonathan M., Evdokimov, Artem, Moseley, M. Arthur, Lewis, Kim, Brennan, Richard G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4831868/
https://ncbi.nlm.nih.gov/pubmed/22999936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.08.013
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