Role of Pairwise Interactions between M1 and M2 Domains of the Nicotinic Receptor in Channel Gating

The adult form of the nicotinic acetylcholine receptor (AChR) consists of five subunits (α(2)βɛδ), each having four transmembrane domains (M1–M4). The atomic model of the nicotinic acetylcholine receptor shows that the pore-lining M2 domains make no extensive contacts with the rest of the transmembr...

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Main Authors: Corradi, Jeremías, Spitzmaul, Guillermo, De Rosa, María José, Costabel, Marcelo, Bouzat, Cecilia
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2007
Teme:
Channels, Receptors, and Electrical Signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697868/
https://ncbi.nlm.nih.gov/pubmed/17028140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.088757
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