Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

A new pyranoindole class of small-molecule inhibitors was studied to understand viral resistance and elucidate the mechanism of inhibition in hepatitis C virus (HCV) replication. HCV replicon variants less susceptible to inhibition by the pyranoindoles were selected in Huh-7 hepatoma cells. Variant...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Howe, Anita Y. M., Cheng, Huiming, Thompson, Ian, Chunduru, Srinivas K., Herrmann, Steve, O'Connell, John, Agarwal, Atul, Chopra, Rajiv, Del Vecchio, Alfred M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693979/
https://ncbi.nlm.nih.gov/pubmed/16940072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00365-06
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