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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

The surface comparison of different serine–threonine and tyrosine kinases reveals a set of 30 residues whose spatial positions are highly conserved. The comparison between active and inactive conformations identified the residues whose positions are the most sensitive to activation. Based on these r...

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Hlavní autoři: Kornev, Alexandr P., Haste, Nina M., Taylor, Susan S., Ten Eyck, Lynn F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693824/
https://ncbi.nlm.nih.gov/pubmed/17095602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607656103
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