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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

The surface comparison of different serine–threonine and tyrosine kinases reveals a set of 30 residues whose spatial positions are highly conserved. The comparison between active and inactive conformations identified the residues whose positions are the most sensitive to activation. Based on these r...

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Detalhes bibliográficos
Main Authors: Kornev, Alexandr P., Haste, Nina M., Taylor, Susan S., Ten Eyck, Lynn F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693824/
https://ncbi.nlm.nih.gov/pubmed/17095602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607656103
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