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Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo
Lentivirus-derived vectors are among the most promising viral vectors for gene therapy currently available, but their use in clinical practice is limited by the associated risk of insertional mutagenesis. We have overcome this problem by developing a nonintegrative lentiviral vector derived from HIV...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1693807/ https://ncbi.nlm.nih.gov/pubmed/17095605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606197103 |
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