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Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

Unlike most chaperones, heat-shock protein 90 (Hsp90) interacts with a select group of “client proteins” that regulate essential biological processes. Little is known about how Hsp90 recognizes and binds these proteins. The glucocorticoid receptor (GR) is a well characterized Hsp90 client protein, w...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fang, L., Ricketson, D., Getubig, L., Darimont, B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693689/
https://ncbi.nlm.nih.gov/pubmed/17130446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609163103
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