Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activate...

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Bibliographic Details
Main Authors: DeBarber, Andrea E., Mdluli, Khisimuzi, Bosman, Marlein, Bekker, Linda-Gail, Barry, Clifton E.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC16924/
https://ncbi.nlm.nih.gov/pubmed/10944230
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