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Strategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosis
Antifolates inhibit de novo folate biosynthesis, whereas ethionamide targets the mycolate synthetic pathway in Mycobacterium tuberculosis. These antibiotics are effective against M. tuberculosis but their use has been hampered by concerns over toxicity and low therapeutic indexes. With the increasin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971469/ https://ncbi.nlm.nih.gov/pubmed/23106273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/eri.12.87 |
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