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ALS-associated mutant SOD1(G93A )causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease that causes motor neuron degeneration, paralysis and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one cause for the familial form of this disease. Transgenic mice expressing mutant SOD1 develo...

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Bibliografske podrobnosti
Main Authors: Higgins, Cynthia MJ, Jung, Cheolwha, Xu, Zuoshang
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC169170/
https://ncbi.nlm.nih.gov/pubmed/12864925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-4-16
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