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Panhandle PCR for cDNA: A rapid method for isolation of MLL fusion transcripts involving unknown partner genes

Identifying translocations of the MLL gene at chromosome band 11q23 is important for the characterization and treatment of leukemia. However, cytogenetic analysis does not always find the translocations and the many partner genes of MLL make molecular detection difficult. We developed cDNA panhandle...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Megonigal, Maureen D., Rappaport, Eric F., Wilson, Robert B., Jones, Douglas H., Whitlock, James A., Ortega, Jorge A., Slater, Diana J., Nowell, Peter C., Felix, Carolyn A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16910/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10920186/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150241797
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