Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

We analyzed the der(11) and der(4) genomic breakpoint junctions of a t(4;11) in the leukemia of a patient previously administered etoposide and dactinomycin by molecular and biochemical approaches to gain insights about the translocation mechanism and the relevant drug exposure. The genomic breakpoi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lovett, Brian D., Lo Nigro, Luca, Rappaport, Eric F., Blair, Ian A., Osheroff, Neil, Zheng, Naiyu, Megonigal, Maureen D., Williams, Wendy Reed, Nowell, Peter C., Felix, Carolyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC55533/
https://ncbi.nlm.nih.gov/pubmed/11493704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171309898
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados