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Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

We analyzed the der(11) and der(4) genomic breakpoint junctions of a t(4;11) in the leukemia of a patient previously administered etoposide and dactinomycin by molecular and biochemical approaches to gain insights about the translocation mechanism and the relevant drug exposure. The genomic breakpoi...

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I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Lovett, Brian D., Lo Nigro, Luca, Rappaport, Eric F., Blair, Ian A., Osheroff, Neil, Zheng, Naiyu, Megonigal, Maureen D., Williams, Wendy Reed, Nowell, Peter C., Felix, Carolyn A.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55533/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11493704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171309898
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