Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6

We used panhandle PCR to clone the der(11) genomic breakpoint junction in three leukemias with t(4;11) and devised reverse-panhandle PCR to clone the breakpoint junction of the other derivative chromosome. This work contributes two elements to knowledge on MLL translocations. First is reverse-panhan...

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Autori principali: Raffini, Leslie J., Slater, Diana J., Rappaport, Eric F., Lo Nigro, Luca, Cheung, Nai-Kong V., Biegel, Jaclyn A., Nowell, Peter C., Lange, Beverly J., Felix, Carolyn A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC123688/
https://ncbi.nlm.nih.gov/pubmed/11930009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062066799
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