Impaired insulin secretion and glucose tolerance in β cell-selective Ca(V)1.2 Ca(2+) channel null mice

Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca(2+) resulting from enhanced Ca(2+) influx through voltage-gated Ca(2+) channels. Mouse β cells express several types of Ca(2+) channel (L-, R- and possibly P/Q-type). β cell-selective ablation of the gene encod...

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Hauptverfasser: Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, Jing, Xing-Jun, Laux, Dirk, Lundquist, Ingmar, Magnuson, Mark A., Obermüller, Stefanie, Olofsson, Charlotta S., Salehi, Albert, Wendt, Anna, Klugbauer, Norbert, Wollheim, Claes B., Rorsman, Patrik, Hofmann, Franz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2003
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC169062/
https://ncbi.nlm.nih.gov/pubmed/12881419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg389
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