Impaired insulin secretion and glucose tolerance in β cell-selective Ca(V)1.2 Ca(2+) channel null mice

Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca(2+) resulting from enhanced Ca(2+) influx through voltage-gated Ca(2+) channels. Mouse β cells express several types of Ca(2+) channel (L-, R- and possibly P/Q-type). β cell-selective ablation of the gene encod...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, Jing, Xing-Jun, Laux, Dirk, Lundquist, Ingmar, Magnuson, Mark A., Obermüller, Stefanie, Olofsson, Charlotta S., Salehi, Albert, Wendt, Anna, Klugbauer, Norbert, Wollheim, Claes B., Rorsman, Patrik, Hofmann, Franz
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2003
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12881419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg389
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!