Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation

An unusual intramembranous cleavage of the β-amyloid precursor protein (APP) by γ-secretase is the final step in the generation of amyloid β-peptide (Aβ). Two conserved aspartates in transmembrane (TM) domains 6 and 7 of presenilin (PS) 1 are required for Aβ production by γ-secretase. Here we report...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Xia, Weiming, Ray, William J., Ostaszewski, Beth L., Rahmati, Talat, Kimberly, W. Taylor, Wolfe, Michael S., Zhang, Jimin, Goate, Alison M., Selkoe, Dennis J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10922078/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.16.9299
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