Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation

An unusual intramembranous cleavage of the β-amyloid precursor protein (APP) by γ-secretase is the final step in the generation of amyloid β-peptide (Aβ). Two conserved aspartates in transmembrane (TM) domains 6 and 7 of presenilin (PS) 1 are required for Aβ production by γ-secretase. Here we report...

Full description

Saved in:
Bibliographic Details
Main Authors: Xia, Weiming, Ray, William J., Ostaszewski, Beth L., Rahmati, Talat, Kimberly, W. Taylor, Wolfe, Michael S., Zhang, Jimin, Goate, Alison M., Selkoe, Dennis J.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC16862/
https://ncbi.nlm.nih.gov/pubmed/10922078
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items