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Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease

Alzheimer’s disease (AD) is characterized neuropathologically by neuronal cell loss, extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Aβ is generated by proteolytic processing of the β-amyloid precursor...

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Bibliografski detalji
Izdano u:Cold Spring Harb Perspect Med
Glavni autori: TCW, Julia, Goate, Alison M.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453386/
https://ncbi.nlm.nih.gov/pubmed/28003277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024539
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