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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
An unusual intramembranous cleavage of the β-amyloid precursor protein (APP) by γ-secretase is the final step in the generation of amyloid β-peptide (Aβ). Two conserved aspartates in transmembrane (TM) domains 6 and 7 of presenilin (PS) 1 are required for Aβ production by γ-secretase. Here we report...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
The National Academy of Sciences
2000
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC16862/ https://ncbi.nlm.nih.gov/pubmed/10922078 |
| Etiketak: |
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