A chromatin insulator protects retrovirus vectors from chromosomal position effects

Recombinant murine retroviruses are widely used as delivery vectors for gene therapy. However, once integrated into a chromosome, these vectors often suffer from profound position effects, with vector silencing observed in vitro and in vivo. To overcome this problem, we investigated whether the HS4...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Emery, David W., Yannaki, Evangelia, Tubb, Julie, Stamatoyannopoulos, George
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2000
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160159597
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