A chromatin insulator protects retrovirus vectors from chromosomal position effects
Recombinant murine retroviruses are widely used as delivery vectors for gene therapy. However, once integrated into a chromosome, these vectors often suffer from profound position effects, with vector silencing observed in vitro and in vivo. To overcome this problem, we investigated whether the HS4...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160159597 |
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