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A chromatin insulator protects retrovirus vectors from chromosomal position effects

Recombinant murine retroviruses are widely used as delivery vectors for gene therapy. However, once integrated into a chromosome, these vectors often suffer from profound position effects, with vector silencing observed in vitro and in vivo. To overcome this problem, we investigated whether the HS4...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Emery, David W., Yannaki, Evangelia, Tubb, Julie, Stamatoyannopoulos, George
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC16837/
https://ncbi.nlm.nih.gov/pubmed/10908661
Tagiau: Ychwanegu Tag
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