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A chromatin insulator protects retrovirus vectors from chromosomal position effects

Recombinant murine retroviruses are widely used as delivery vectors for gene therapy. However, once integrated into a chromosome, these vectors often suffer from profound position effects, with vector silencing observed in vitro and in vivo. To overcome this problem, we investigated whether the HS4...

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Detalhes bibliográficos
Main Authors: Emery, David W., Yannaki, Evangelia, Tubb, Julie, Stamatoyannopoulos, George
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16837/
https://ncbi.nlm.nih.gov/pubmed/10908661
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