Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation

Previous clinical attempts to correct genetic deficiencies such as hemophilia or Gaucher disease by transplantation of allogeneic spleen were associated with aggressive graft versus host disease, mediated by mature T cells derived from the donor spleen. We show that a fetal pig spleen harvested at t...

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Bibliographic Details
Main Authors: Aronovich, Anna, Tchorsh, Dalit, Katchman, Helena, Eventov-Friedman, Smadar, Shezen, Elias, Martinowitz, Uri, Blazar, Bruce R., Cohen, Sivan, Tal, Orna, Reisner, Yair
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1682010/
https://ncbi.nlm.nih.gov/pubmed/17148607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607012103
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