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Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation
Previous clinical attempts to correct genetic deficiencies such as hemophilia or Gaucher disease by transplantation of allogeneic spleen were associated with aggressive graft versus host disease, mediated by mature T cells derived from the donor spleen. We show that a fetal pig spleen harvested at t...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1682010/ https://ncbi.nlm.nih.gov/pubmed/17148607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607012103 |
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