Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors

The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) is essential for growth, differentiation, and development. Its biological activities are mediated by T3 nuclear receptors (TRs). At present, how T3 regulates TR proteins and the resulting functional consequences are still unknown. Immunofluorescenc...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Dace, Alexandra, Zhao, Li, Park, Kyung Soo, Furuno, T., Takamura, N., Nakanishi, M., West, Brian L., Hanover, John A., Cheng, Sheue-yann
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16808/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908671/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160257997
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