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Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors

The thyroid hormone 3,3′,5-triiodo-l-thyronine (T3) is essential for growth, differentiation, and development. Its biological activities are mediated by T3 nuclear receptors (TRs). At present, how T3 regulates TR proteins and the resulting functional consequences are still unknown. Immunofluorescenc...

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Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Dace, Alexandra, Zhao, Li, Park, Kyung Soo, Furuno, T., Takamura, N., Nakanishi, M., West, Brian L., Hanover, John A., Cheng, Sheue-yann
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 2000
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16808/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908671/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160257997
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