Diminished RNA Primer Usage Associated with the L74V and M184V Mutations in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Provides a Possible Mechanism for Diminished Viral Replication Capacity

The emergence of drug resistance-conferring mutations can severely compromise the success of chemotherapy directed against human immunodeficiency virus type 1 (HIV-1). The M184V and/or L74V mutation in the reverse transcriptase (RT) gene are frequently found in viral isolates from patients treated w...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Diallo, Karidia, Marchand, Bruno, Wei, Xin, Cellai, Luciano, Götte, Matthias, Wainberg, Mark A.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2003
Θέματα:	Replication
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC167213/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12885880/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.16.8621-8632.2003
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