Diminished RNA Primer Usage Associated with the L74V and M184V Mutations in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Provides a Possible Mechanism for Diminished Viral Replication Capacity

The emergence of drug resistance-conferring mutations can severely compromise the success of chemotherapy directed against human immunodeficiency virus type 1 (HIV-1). The M184V and/or L74V mutation in the reverse transcriptase (RT) gene are frequently found in viral isolates from patients treated w...

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Detalhes bibliográficos
Main Authors: Diallo, Karidia, Marchand, Bruno, Wei, Xin, Cellai, Luciano, Götte, Matthias, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC167213/
https://ncbi.nlm.nih.gov/pubmed/12885880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.16.8621-8632.2003
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