Design of a potent and selective inhibitor of the intermediate-conductance Ca(2+)-activated K(+) channel, IKCa1: A potential immunosuppressant

The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wulff, Heike, Miller, Mark J., Hänsel, Wolfram, Grissmer, Stephan, Cahalan, Michael D., Chandy, K. George
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16685/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884437/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.8151
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