Design of a potent and selective inhibitor of the intermediate-conductance Ca(2+)-activated K(+) channel, IKCa1: A potential immunosuppressant

The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-activated K(+) channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and diarrhea and is effective in ameliorating the symptoms of rheumatoid arthritis. However, inhibition of cytochrome...

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Bibliographic Details
Main Authors: Wulff, Heike, Miller, Mark J., Hänsel, Wolfram, Grissmer, Stephan, Cahalan, Michael D., Chandy, K. George
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC16685/
https://ncbi.nlm.nih.gov/pubmed/10884437
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