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Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments

T cell receptor (TCR) β variable region genes are assembled in progenitor T cells from germ-line Vβ, Dβ, and Jβ segments via an ordered two-step process in which Dβ to Jβ rearrangements occur on both alleles before appendage of a Vβ to a preexisting DJβ complex. Direct joining of Vβ segments to nonr...

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Kaydedildi:
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Sleckman, Barry P., Bassing, Craig H., Hughes, Maureen M., Okada, Ami, D'Auteuil, Margaux, Wehrly, Tara D., Woodman, Barbara B., Davidson, Laurie, Chen, Jianzhu, Alt, Frederick W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2000
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16655/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10869424/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.130190597
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