Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments

T cell receptor (TCR) β variable region genes are assembled in progenitor T cells from germ-line Vβ, Dβ, and Jβ segments via an ordered two-step process in which Dβ to Jβ rearrangements occur on both alleles before appendage of a Vβ to a preexisting DJβ complex. Direct joining of Vβ segments to nonr...

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Main Authors: Sleckman, Barry P., Bassing, Craig H., Hughes, Maureen M., Okada, Ami, D'Auteuil, Margaux, Wehrly, Tara D., Woodman, Barbara B., Davidson, Laurie, Chen, Jianzhu, Alt, Frederick W.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16655/
https://ncbi.nlm.nih.gov/pubmed/10869424
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