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Robustness and Fragility in Immunosenescence
We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is associat...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664698/ https://ncbi.nlm.nih.gov/pubmed/17121459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020160 |
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