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Coevolutionary Immune System Dynamics Driving Pathogen Speciation

We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the development of chronic infection, rather than quick pathogen c...

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Detalhes bibliográficos
Main Authors: Schlesinger, Kimberly J., Stromberg, Sean P., Carlson, Jean M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108359/
https://ncbi.nlm.nih.gov/pubmed/25054623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102821
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