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Robustness and Fragility in Immunosenescence
We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is associat...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664698/ https://ncbi.nlm.nih.gov/pubmed/17121459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020160 |
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